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Hematology

EHA

Milan

Poster

BMS-986458, a first-in-class, bifunctional, cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6) in patients with relapsed/refractory non-Hodgkin lymphoma: initial phase 1 results

Franck Morschhauser, David Qualls, Jennifer Lue, Anastasios Stathis, Marcel Nijland, Noémie Lang, Jörg Bittenbring, Guillaume Cartron, Avyakta Kallam, Loïc Ysebaert, Vladan Vucinic, Jonathan Kolitz, Noelia Purroy, Bérengère de Moucheron, Alicia Benítez Rondán, Joseph Burnett, Carla Guarinos, Xiaosong Li, Michael Pourdehnad, Jean-Marie Michot.

Poster

Characterizing real-world treatment utilization and clinical outcomes in patients with relapsed/refractory multiple myeloma after lenalidomide and anti-CD38 exposure in the United States

Andrew J. Cowan, Amol D. Dhamane, Amanda Crosbie, Amir Samuel, Antoine Tinel, Jessica Katz.

Poster

Development of a risk stratification algorithm in triple-class exposed and double-class exposed relapsed/refractory multiple myeloma using the Flatiron Health database

Michel Delforge, Karthik Ramasamy, Clyde Caisip, Shannon Cope, Devender Dhanda, Thomas Debray, Yu-Hsuan Shih, Walter Bouwmeester.

Poster

Evaluating Luspatercept as a Superior Treatment for Enhancing Clinical and HRQoL Outcomes in Transfusion-dependent Patients with Lower-risk MDS: Results from Phase 3 COMMANDS Study

Esther N. Oliva, Mikkael A. Sekeres, Christopher G. Pelligra, Shien Guo, Yutian Mu, Ahmed Hnoosh, Dimana Miteva, Aylin Yucel.

Poster

Iberdomide, bortezomib, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: updated results from the CC-220-MM-001 trial

Darrell White, Brea Lipe, Mercedes Gironella Mesa, Ruben Niesvizky, Albert Oriol, Anna Sureda Balari, Manisha Bhutani, Cristina Encinas, Abdullah M. Khan, Michael Amatangelo, Danny Jeyaraju, Kexin Jin, Thomas Solomon, Kevin Hong, Alpesh Amin, Olumoroti Aina, Paulo Maciag, Niels W.C.J. van de Donk, Sagar Lonial.

Poster

Iberdomide treatment enhances manufactured CAR T cell expansion and functionality and is immunostimulatory in patients post CAR T cell therapy

Adolfo Aleman, Michael Amatangelo, Leah Grossman, Shriya Desai, Sidorela Reci, Danny Jeyaraju, Anita Gandhi, Samir Parekh.

Poster

Impact of luspatercept versus epoetin alfa treatment on genomic landscape and mutational burden in patients with lower-risk myelodysplastic syndromes in the COMMANDS trial

Rami S. Komrokji, Manuel Ugidos, Maroof Hasan, Matthew E. Stokes, Guillermo Garcia-Manero, Matteo Giovanni Della Porta, Amer M. Zeidan, Valeria Santini, Uwe Platzbecker, Anita K. Gandhi, Daniel L. Menezes, Rajasekhar N.V.S. Suragani.

Poster

Mezigdomide in novel combinations effectively reactivates immune system in patients with relapsed/refractory multiple myeloma including those after T cell redirecting therapies

Antonina Kurtova, Julia Santucci-Pereira, Alberto Risueño, Mandeep Takhar, Luciano J. Costa, Fredrik Schjesvold, Rakesh Popat, David Siegel, Monique A. Hartley-Brown, Saad Z. Usmani, Syed Abbas Ali, Nizar J. Bahlis, Michael P. Chu, Albert Oriol, Karthik Ramasamy, Joaquín Martínez-Lopez, Enrique M. Ocio, Donna Reece, Emma Searle, Rafael Sarmiento, August Dietrich, Daniel W. Pierce, Ann Mongan, Paul G. Richardson.

Poster

Mezigdomide in novel combinations for relapsed/refractory multiple myeloma: updated results from the CA057-003 trial

Luciano J. Costa, Fredrik Schjesvold, Rakesh Popat, David S. Siegel, Saad Z. Usmani, Syed Abbas Ali, Michael P. Chu, Monique A. Hartley-Brown, Nizar J. Bahlis, Albert Oriol, Joaquín Martínez-Lopez, Enrique M. Ocio, Karthik Ramasamy, Donna Reece, Emma Searle, Allison Gaudy, Antonina Kurtova, Wen Zhang, Rafael Sarmiento, August Dietrich, Jessica Katz, Michael Pourdehnad, Paul G. Richardson.

Poster

Preliminary efficacy and safety analysis of the MAXILUS study of luspatercept initiated at the maximum approved dose in transfusion-dependent lower-risk myelodysplastic syndromes

Matteo Giovanni Della Porta, Maria Diez Campelo, Valeria Santini, Rena Buckstein, Lionel Adès, Lea Sahagun, Gitanjali Das, Tanisha Bryant, Tatiana Zelinsky, Yinzhi Lai, Dimana Miteva, Ali McBride, Krzysztof Madry, David Valcarcel, Jose Miguel Torregrosa-Diaz, Dries Deeren, Sebastian Grosicki, Sangeetha Venugopal, Uwe Platzbecker, Amer M. Zeidan.

Poster

Real-world treatment patterns and clinical outcomes in patients with relapsed/refractory multiple myeloma with 2–4 lines of treatment in the PREAMBLE registry

Ravi Vij, Claudio Cerchione, David Cella, Yu-Hsuan Shih, Jiaqi Fang, Katie Gravagna, Amanda Crosbie, Gabriela Hernandez-Rivera, Jing Bo Li, Karthik Ramasamy.

Poster

Relationship between hemoglobin and quality of life in non-transfusion-dependent patients with myelofibrosis treated with luspatercept

Haifa Kathrin Al-Ali, Rami Komrokji, Christopher G. Pelligra, Fabián Sanabria, Patricia Martin-Regueira, Shien Guo, Yeran Li, Aaron T. Gerds.